Education:
1963-1966 B.A. with Honors in Chemistry, summa cum laude, Brandeis University, Waltham, Mass.; studies completed in three years, degree conferred in June, 1967
1966-1972 M.D.-Ph.D., New York University School of Medicine; dissertation in the Department of Biochemistry
Employment:
1972-1974 Medical intern and resident, Johns Hopkins Hospital, Baltimore, MD 21205
1974-1977 Research Associate and Pulmonary Fellow, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
1977-1979 Staff Investigator, Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
1979-1994 Head, Section on Molecular Mechanisms, Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
1979-1994 Physician, Medical Intensive Care Unit, Clinical Center, National Institutes of Health, Bethesda, MD 20892
1986-1994 Deputy Chief, Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
1993-1994 Acting Chief, Pulmonary Branch, National Heart, Lung, and
Blood Institute, National Institutes of Health, Bethesda, MD
1994-2007 Chief, Pulmonary-Critical Care Medicine Branch, National Heart,
Lung, and Blood Institute, National Institutes of Health,
Bethesda, MD
2007-2010 Deputy Chief, Translational Medicine Branch, National Heart,
Lung, and Blood Institute, National Institutes of Health,
Bethesda, MD
2007- Head, Translational Research Section, National Heart,
Lung, and Blood Institute, National Institutes of Health,
Bethesda, MD
2007- Head, LAM Research Program, National Heart,
Lung, and Blood Institute, National Institutes of Health,
Bethesda, MD
2010- Deputy Chief, Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
2014(Dec) – Interim Deputy Clinical Director, Cardiovascular and
2015(Feb) PulmonaryBranch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
Professional Certification:
1975 Diplomate in Internal Medicine
1978 Diplomate in Pulmonary Disease
1987-1997 Diplomate in Critical Care Medicine
Honors and Awards:
1963 New York State Regents Scholarship
1964-1965 Louis D. Brandeis Honorary Scholar
1966 Phi Beta Kappa
1966 New York State Regents Scholarship for Professional Study
1966 New York University School of Medicine Admission Scholarship Award
1967 Melvin M. Snider Graduation Chemistry Award
1970 American Oil Chemists' Society Honored Student Award
1973 Founder's Day Award, New York University
1981 Passano Foundation Young Scientist Award for 1981
1982 Public Health Service Commendation Medal
1985 Cancer Research Campaign Lecture, Third Annual Workshop on ADP-ribosylation of Protein, Reading, U.K.
1987 American Federation for Clinical Research Young Investigator Award for Clinical Research
1989 Public Health Service Meritorious Service Medal
1996 Introductory Speaker, "Biological Significance of Mono-ADP-ribosylation in Animal Tissues" Hamburg, Germany; May 19-23, 1996.
1996 Visiting Lecturer, Alberta Heritage Foundation for Medical Research, University of Calgary, Alberta, Canada
1998 National Institutes of Health Director’s Award
1999 LAM Foundation Award
2000 Honorary Member, Peruvian Thoracic Society
2003 EEO Special Achievement Award
2004 Chiba University School of Medicine/Chiba Medical Society Silver Medal
2007 New York University School of Medicine: Alumnus Inductee of the Alpha Omega Alpha (AOA) Honor Society Delta Chapter of New York
2009 New York University School of Medicine: The Solomon A. Berson Medical Alumni Achievement Award in Basic Science
2009 Elected to John Hopkins University Society of Scholars
2010 LAM Foundation Scientific Achievement Award
2010 Fellow, American College of Chest Physicans
2012 Orloff Science Award, NHLBI Division of Intramural Research, Team Lead: For molecular insights that led to target therapies for lymphangioleiomyomatosis (LAM)
2012 Chiba Medical Society Award, Chiba, Japan
2013 Learning Environment Award, NHLBI Director’s Award, Bethesda, MD.
Professional Affiliations:
Member, American Society of Biological Chemists (1977)
Member, American Society for Clinical Investigation (1979)
Member, Association of American Physicians (1991)
Member, American Thoracic Society (1993)
Member, American College of Chest Physicians (2010)
Elected Advisory Positions:
1987-1990 Councillor, American Society for Clinical Investigation
1990-1991 Vice-President, American Society for Clinical Investigation
NIH Intramural Advisory Committees:
1980-1981 Secretary, Assembly of Scientists, NHLBI
1988-2006 Institutional Review Board, NHLBI
1988-2004 Promotion Tenure Review Board, NHLBI
1988 Organizing Committee, NIH Research Day
1989-1994 Pharmacology Research Associate (PRAT) Program Advisory Committee
1991-present Advisor, NRC Research Associateship Program
1994-present Subcommittee on Cooperative Research and Development Agreements, NIH Patent Policy Board
1994-present Technology Evaluation Advisory Committee
1994-1995 Chair, Pharmacology Research Associate Program Advisory
Committee
1995 NHLBI Transgenic Support Service Committee
1995 NIDR Tenure Track Advisory Committee
1995-1998 Howard Hughes Medical Institute-NIH Research Scholars Program Advisory Committee
1995-2006 Chair, NHLBI Institutional Review Board (IRB)
1996 Member, Committee on Recruitment of Clinical Researchers, NIH
1996-2002 Member, General Loan Repayment Committee, NIH
1997 Member, Committee on Extramural/Intramural Investigations in the Clinical Center, NIH
1997 Search Committee: NHLBI, Veterinarian
1997-present Member, Advisory Committee for Clinical Researchers for the Central Tenure Committee, NIH, IR
1997 Member, Senior Executive Search Committee, Deputy Director, NHLBI
2002 Member, Tenure Track Search Committee, Cardiovascular Branch,
NHLBI
2002 Chair, Clinical Director Search Committee, NHLBI
2002 Member, Panel, Biomedical Research Training Program for
Underrepresented Minorities (BRTPUM), NHLBI
2002-present Proteomic Core Committee
2002-present Pathology Core Committee
2003-2005 Chair: Title 42 Standing Committee
2005-present Clinical Research Training Program Admission Committee
2006 Member, Panel 3, NIH IC Symposium on Population Genomics
2006 Member, NHLBI Strategic Planning Process – Lung Program
Theme #4 Working Group: Personalized Medicine
2006- Member, Trans-NIH Coordinating Committee for Lymphatic Research
2006-2007 Clinical Imaging Sciences Department Search Committee
2007- GAIN Data Access Committee
2007-2008 Member, NHLBI Tenure Track Search Committee for Clinical Research
2008- Chair, Pathology Core Steering Committee
2008-2009 Member, Pulmonary Medicine Branch Chief Search Committee
2008-2009 Member, DIR Data Management Advisory Group
2009 Member, Earl Stadtman Tenure Track Investigator Search Committee:
Clinical Research
2009-2010 Member of PHEMCE Chemical Requirements WG, Biomedical
Advanced Research & Development Authority (BARDA)
2010 Member, Earl Stadtman Tenure Track Investigator Search Committee:
MolecularBiology/Biochemistry Committee
2011- Member, FACS Core Steering Committee
2011 Member, Stadtman Tenure-track Search Committee for Molecular Biology and Biochemistry
2011-2012 Member, Working Group for NIH Performance Management Appraisal Program (PMAP)
2012 Member, Earl Stadtman Search Committee – Molecular Biology/Biochemistry
2012-2013 Member, NHLBI Clinical Director Search Committee
2012- Member, Technology Transfer Policy Board (alternate for Dr. Gerfen Chair, CRADA subcommittee)
2012- Member, NHLBI Search Committee for Staff Clinican
2013 Member, Earl Stadtman Search Committee – Molecular Biology/Biochemistry
2014 Member, Earl Stadtman Search Committee – Molecular Biology/Biochemistry
Editorial Positions:
1982-1987 Editorial Board, Journal of Biological Chemistry
1985 Co-editor, "Pertussis Toxin", Academic Press, Inc., New York, NY
1990 Co-editor of "ADP-ribosylating Toxins and G Proteins", (American
Society for Microbiology, Washington, D.C., publishers)
1991-1996 Editorial Committee, The Journal of Clinical Investigation
1992-1997 Editorial Board, Journal of Biological Chemistry
1994 Co-Editor, "ADP-Ribosylation: Metabolic Effects and Regulatory Functions", focused issue of Molecular and Cellular Biochemistry, Kluwer Academic Publishers, Dordrecht, The Netherlands
1995 Co-editor of "Handbook of Bacterial Toxins", Volume 8 (Marcel Dekker, Inc., New York, New York, Publishers)
1998- Editorial Board, American Journal of Respiratory Cell & Molecular Biology
1998-2003 Editorial Board, Journal of Biological Chemistry
1998-Present Editorial Board, The American Journal of the Medical Sciences
1999 Editor, "LAM and Other Diseases Characterized by Smooth Muscle Proliferation" for the series "Lung Biology in Health and Disease", executive editor, Claude Lenfant, Marcel Dekker, New York, New York
2000 Co-editor, "Paroxysmal Nocturnal Hemoglobinuria", Academic Press, San Diego, California
2001 Editor, "Clinical Insights from Uncommon Lung Diseases", focused issue of The American Journal of The Medical Sciences. Decatur, Georgia, 2002
2002 Co-author with Jordan Prutkin of text “Genetics for Pulmonologists.”
Remedica, London, United Kingdom.
2003- Associate Editor, Encyclopaedia of Respiratory Medicine, Elsevier, Oxford, UK.
2005- Faculty Member, Faculty of 1000 Medicine, United Kingdom, 2005.
2005 Editor, Encyclopedia of Dietary Supplements (1st edition), Marcel Dekker, New York.
2006 Co-author with Dr. Evan DeRenzo of “Writing Clinical Research
Protocols: Ethical Considerations.” Elsevier, Academic Press, San Diego, CA, 2006.
2007-2012 Editorial Board, CHEST
2007 - External Reviewer, Canadian Cystic Fibrosis Foundation, Toronto, Ontario, Canada.
2009- Section Editor in Signalling for the Encyclopaedia of Biological Chemistry, Elsevier, Burlington, MA.
2010- Foreign Editor, Tohoku Journal of Experimental Medicine
2010 Guest Editor, Lymphatic Research and Biology, focused issue on LAM
2010-2015 Associate Editor, CHEST
2010 Editor, Encyclopedia of Dietary Supplements (2nd edition),Informa Healthcare, New York, London.
2014- Member, International Advisory Board, Juntendo Medical Journal, Tokyo, Japan.
Direction of Research:
1) Reconstitution of protein trafficking systems with 20-kDa guanine nucleotide-binding ADP-ribosylation factors and associated regulatory proteins.
2) Role of bacterial virulence factors in lung disease.
3) Genetic factors in lung disease.
4) Pathogenesis of lymphangioleiomyomatosis (LAM).
5) Regulation of ADP-ribosylation cycles in animal cells; characterization and cloning of ADP-ribosyltransferases, ADP-ribosylarginine hydrolases and their substrates.
Cardiovascular and Pulmonary Branch
National Heart, Lung, and Blood Institute
National Institutes of Health